I think VQ swaps make more sense than some other more popular swaps, these are my opinions:
Weight
A 240z weight about 1,000kgs or 2,200lbs. L2x engine is I6 and iron block somewhere around 350lbs (?), VQ are all alloy around 330lbs (?). I suspect the two engine engines weight about the same, VQ being twin cam and 24v etc. After the swap, the overall weight won't go up by much, if at all.
Weight placement
VQ will sit further back, mostly if not all behind the front axle, making the finished car a front mid engine.
Center of gravity
Lower center of gravity is the goal, VQ being a V engine helped some here but may not be much with twin cams and all.
Power to weight
VQ35HR has 305 hps, that would be 305 hp/2200lbs, that is 1hp for 7.3 lbs, for perspective, Ferrari F430 - 1517 Kgs (3344 lbs) with 483 hps that would be 1hp for 6.92lbs.