My car has 16" Konig rewinds on it with 225/50-16 rear tires and 215/50-16 front tires. I have urethane bushings, Tokico HP struts, and Tokico springs. The rear tires rubbed the fenders on big bumps until I rolled the fender lips. Also, I had to trim my MSA Type II front airdam so the tires wouldn't rub when turning.
Now about those brakes... I have Toyota 4x4 calipers and vented rotors on the front of my car. I don't have any clearance issues with the rotors. However, I am using the S12+8 calipers, not the S12W calipers. The S12W calipers are a bit bigger and rubbed my wheels SLIGHTLY when I test fit them. The rubbing could easily have been fixed by grinding some material off caliper's "vent ribs" as Derek mentioned.