E10 could cause in increase in pre-ignition, if the EMS is not able to cater for the increased fuelling requirements, and you were already running a little lean on Gasoline etc.
As for destructive detonation - I highly doubt that E10 would cause a perfect motor to grenade without some other significant contributing factors.
You can potentially squeeze a few more HP out of an 'E' blend, as it tends to be rated at a higher octane. There are a few brands of 98RON PULP available here in South Australia that have an Ethanol content (but not as high as 10%), and I'm fairly confident that I get nicer running from my RB25DET with this fuel than plain-Jane 98RON (rated) Gasoline. The economy suffers a little, but she's a happier engine on the whole.
Pure methanol is a different story (~6:1 AFR's, corrosive, and more power - potentially), and I'd only ever run water injection - but that's a climate issue. It never gets cold enough here to warrant the anti-freeze attributes that the tiny % of Methanol brings to the water/meth blend. And that's what the Meth is there for; not more power, but anti-freeze.
Solving the detonation problem is best attacked form many angles - charge cooling, sane boost, good mixtures, sensible timing, spot-boiling control (which thanks to this thread I have learnt a lot more about), and anti-detonants (choose your poison!).