Well if the tires are hmmm less than 3 years old and is use on the regular, parked outside (don’t they all )etc.. It can be a lot of factors, if you wish, begin checking the DOT, once that is done and you’re please with the result, then check the bearings on the hub, sometimes one overlook that minor factor until you loose a wheel on the freeway. I usually replaced my bearings on my trailer hmmm every 3,000 miles plus or minus.
Hope this help a bit,
Alex