OK, this is pretty broad and really only specific to the engine I had in my car, but here goes:
With the 6 - 2- 1 header its possible to tune its two torque peaks (not really peaks, just high points I guess) to span some band of rpm. The area between the peaks remains relatively flat so the torque curve may not be as high as with an optimally designed 6 - 1 header but you can end up with a broader torque curve and possibly more area under the curve. It takes a lot of dyno time (15 hours in my engine's case) and involved a lot of work in other areas of the engine but it can be done.
Notice all the vagueness with words like "can", "possible", "possibly", "may", etc. Without testing you'll never really know what you've achieved.