A large wheel cannot handle the speeds a smaller wheel can and doesn't run at the same speeds. Kinda like diesel motors.
If you compare a T3 60 trim (stock 280ZX turbo) and a T4 with a 62-1 compressor wheel. They will both make 300 hp. The T3 wheel is about at the end of the map and the efficiency is lower, making more heat, requiring more boost to make the same power. The T3 turbine wheel is also alot smaller than a T4 wheel or upgraded T3 wheel. While it will spool faster it will not flow nearly as much or have the torque to turn a large compressor wheel. If run with a large compressor wheel it will have more backpressure to make the same boost. You have to compare both the compressor and turbine side. Yes some on this board run T3/4's with stock turbine wheels. They also don't make the power they could be making.
Hopefully these come up. 16 psi intercooled is about a 2.2 PR. Close to the safe limit on pump gas. It is enough to make 350 rwhp/400hp+ crank (yes not everyone makes that but again most use a T3 turbine wheel). 10lbs/min is about 10 hp. You can see the T3 compressor is way off the map. It is living on barrowed time. The other 2 are still good. If you wanted to run more octane and 23 psi the T4 E60 would be to small too. The 62-1 would work though.