I found this to be especially true on forced induction.
It was a different engine (not an L-series), but it was a creation of my own. 3.2L V6, T3 turbo, Mitsu Satrion FMIC, home made headers, 8.9:1 SCR, Crane 260-2 cam, 2.5" exhaust, with cat and either no muffler or Supertrapp muffler (sorry I don't recall if I had the muffler removed by that time), 1985 GMC Jimmy, somewhere around 3200 lbs, 3.73 final drive gear.
Anyway I had a 56mm TB, ran a best of with that TB of about 14.2 IIRC, swapped the TB to a 52mm, and immediatly ran a 13.8. Now, this may not have been just an issue of too large a TB, because I am confidant I would have been able to use the 56mm TB, provided I had a better flowing intake manifold. So I think it was more of a matching between the TB and what was behind that TB in matching flow.