This is quite a statement, and I just can't agree entirely. I have drive a 4bbl car that was well setup, and I have had many SU cars, and customers cars to draw this view on. Carbs just plain and simple, don't get any easier than SU's. I had a set on a daily driven Z for 2.5 years, and drivability was excellent. Milage was in the area of 20mpg city and 25mpg highway. Started right away every time with the choke on when needed. (this might be a negative for some, but seriously how hard is it to use a manual choke?) The only thing I would agree that the 4bbl setup had over the SU's was top end airflow, and possibly the gas milage because I hadn't driven the 4bbl car enough to know what kind of milage it got.
After adding up all the parts you need for a 4bbl conversion, a set of Z therapy SU's are about the same price.
My only recommendation is this. If you know Holley carbs, go ahead and use it. If you know SU's, use them. If you don't know either, the SU's are much easier to tune with only a couple specialty tools that combined cost about $50.
Or just go with triples and let the car sing.