Well, just to play the game, it would take custom engine mounts, a custom transmission adapter, custom headers, dealing with all the accessory & intake problems that a FWD setup has when trying to install into a RWD config and so much more.
Heck, if the FWD SR20 doesn't work where the RWD version does (in a 510 or Z), then you can see why this really isn't worth the effort. If you had a bottomless pocketbook and were doing it just to be different, then you can make anything work. If you are looking for ease of install and best "bang for the buck" with a V8 conversion, the SBC or LSX is really the best way to go. (of course, some Ford & Mopar guys may disagree!)