1st - one should always be concerned with detonation, and avoid it at all costs.
That said, I agree that 12.5 - 12.7 is where you whould be under boost, not 10.5 - you're losing HP and gas.
You can also lose HP if timing is not right, as well as mileage.
I am about to go MSNS_E,and will be using a knock sensor when tuning, and edge up on the right settings.
If you check out the MSEFI forum, you can see a vendor that can supply something that will interface with MS and datalog.
It costs ~$60 dollars, anhd I believe it will be money well spent.