Except from the getgo, Carlos Gohsn has said the car is being designed for the US market. Its left hand drive, and is coming out, they've been seen testing on the nurburgring. (In a G35 body).
Yes the G35 is the skyline in japan, but the new GTR will not be a skyline, simply GTR. Whether its infiniti or nissan remains to be seen, but Im guessing Infiniti